Which is a sign of digoxin toxicity?

• A. Hypertension
• B. Hair loss
• C. Nausea and vomiting
• D. Weight gain

Answer: (C)

Digoxin toxicity most commonly presents with gastrointestinal symptoms, particularly nausea and vomiting. This is a classic early sign because high digoxin levels irritate the GI tract and can also affect the central nervous system, leading to nausea, vomiting, and sometimes abdominal pain. Hypertension isn’t typical of digoxin toxicity; if anything, toxicity often leads to bradycardia or various arrhythmias rather than high blood pressure. Hair loss isn’t associated with digoxin toxicity, and weight gain alone isn’t a specific toxicity sign—it can reflect fluid retention from heart failure rather than a toxic effect of the drug. If these symptoms occur, evaluating digoxin level, renal function, and potential drug interactions is important.