Statins should be avoided in patients with which condition due to risk of liver injury?

• A. Hepatic or biliary disease
• B. Renal failure
• C. Diabetes mellitus
• D. Atherosclerosis

Answer: (A)

Statins are processed by the liver, and they carry a risk of hepatotoxicity. In patients with hepatic or biliary disease, liver function is already compromised, so adding a statin can further impair the liver and raise the chance of liver injury. That’s why hepatic or biliary disease is the situation where statins should be avoided. Renal failure, diabetes, and atherosclerosis are not absolute contraindications; statins are commonly used in these conditions with appropriate monitoring and dose adjustments as needed.