ACE inhibitors action?

• A. They block beta receptors in the heart
• B. They increase renin release
• C. They cause bronchoconstriction
• D. They prevent conversion of angiotensin I to II and reduce aldosterone

Answer: (D)

ACE inhibitors work by blocking the enzyme that converts angiotensin I into angiotensin II. This reduces angiotensin II–mediated vasoconstriction and lowers aldosterone release, which decreases sodium and water retention and ultimately lowers blood pressure. The statement that matches this primary mechanism is the one describing the prevention of angiotensin I to II conversion and the consequent reduction in aldosterone.

It’s true that renin release can rise with ACE inhibition due to loss of negative feedback, but that is an indirect effect and not the defining action of these drugs. The other options describe actions that belong to different drug classes (beta blockers) or are not characteristic effects of ACE inhibitors (bronchoconstriction).